Comt Gene Could Be Why You Can’t Stop Overthinking

Have you ever found yourself replaying a conversation in your head until it feels like a broken record? If you’re nodding, you might be familiar with the COMT gene. In this episode, Stephen Martin uncovers how variations in COMT can add extra chatter to an already busy mind, especially for those of us who are neurodivergent or have ADHD.

By exploring the traits of “worrier” types, the fragile nature of sleep, and the potential effects of things like caffeine, Stephen paints a practical picture of gene-based health. If you’ve ever wondered why your mind sprints circles while waiting in line, this conversation might provide the insights you’ve been seeking.

What Is the COMT Gene?

The COMT gene impacts how your body breaks down dopamine and other chemicals linked to motivation, stress, and mood. It acts like a little switch in your brain that controls how quickly or slowly these neurotransmitters are cleared out. As Stephen puts it, the COMT “worrier” variation can ramp up anxiety and make emotions feel extra sharp.

For those of us who are neurodivergent, having this gene variation can heighten daily experiences. Minor events may feel like landmines waiting to trigger stress. You might be planning every possible outcome, even if you only popped to the shops for milk.

Worrier vs Warrior

In the podcast, Stephen mentions there’s often talk of “worrier” vs “warrior” variations of the COMT gene. The difference lies in how your body processes dopamine, which has a direct impact on anxiety, focus, and emotional reactions. Worriers might find their minds looping over details, while warriors often sail through challenges at lightning speed.

“For many of us with the COMT gene, we can feel edgier on stimulant medication, so it’s crucial to explore a personalised approach.”

If you’re a worrier, you may try to avoid conflict at all costs or second-guess yourself long after a conversation ends. For some, that can turn into physical discomfort, like a churning stomach or tight muscles. Warrior types, on the other hand, might crave risk and not dwell as much on each decision.

Daily Life with the COMT Gene

One of the fascinating points from the episode is how caffeine can hit worriers harder. You’re not imagining that extra jolt. The COMT variation tends to amplify stimulants, which can leave you jittery or anxious when everyone else is on their third cup of coffee.

Sleep can also feel fragile. Tossing and turning at night may happen because your brain has trouble switching off lingering thoughts. A predictable evening routine can be a game changer. When your mind knows what to expect, it’s easier to wind down.

Here are a few other common experiences:

• Replaying social interactions and wondering if you said the wrong thing.
• Worrying about multiple hypothetical outcomes before they happen.
• Feeling physically on edge from small issues, like an unexpected phone call.
• Noticing that stimulant medication can feel too harsh without careful dosing.

Managing the Effects

Stephen emphasises that knowing your genetic makeup can guide you towards smarter choices. If you know caffeine makes your heart pound, try decaf or limit that afternoon latte. If fragile sleep is a struggle, explore magnesium or other supportive supplements that can settle your nervous system.

Routine and predictability also go a long way. Small adjustments, like making a morning checklist or setting reminders, can calm the constant hum of “what if” scenarios. Tailoring your environment matters too. If you’re working from home, carve out a quiet, clutter-free corner. Create boundaries around noise and interruptions so your brain can focus without piling on extra stress.

Finally, consider genetic testing if you’re curious about more personalised support. Hearing an expert’s take on your own COMT variant can be a relief. It might also open doors to strategies that suit your unique biology.

Looking Ahead

There’s a lot to explore if this gene resonates with you. Being aware of it is the first step. Even minor tweaks to your diet, supplements, or routine can calm that spinning mind. If you also have ADHD or dyslexia, remember that next-level knowledge about your genes could lead to more effective support.

You don’t have to let your thoughts run the show. Many of us worried we were “just anxious.” Realising there’s a biological basis for part of that stress can be empowering. It’s not that you’re doing life wrong. You just have a body that processes stress hormones in a unique way, which might require a different toolbox.

Final Takeaways

• The COMT gene influences brain chemistry, especially how dopamine and stress hormones are processed.
• Worrier types often replay events, feel physical discomfort more intensely, and may have more fragile sleep.
• Limiting caffeine and building a clear daily routine can reduce stress.
• Stimulant medication can feel harsh, so talk to a healthcare professional about adaptations.
• Gene testing can offer insights that help manage ADHD, dyslexia, and anxiety.

If this topic intrigues you, don’t miss the full conversation at the top of this page. Stephen’s insights might spark ideas, calm your worries, and help you understand why your brain does what it does. Take a listen and discover new ways to thrive, COMT gene or not.